Abstract The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein. an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed. which can dilate vessle and improve the drug penetration by in situ releasing nitric oxide (NO). https://www.markbroyard.com/best-save-happy-way-ashy-bines-whey-protein-powder-choc-caramel-500g-online-sale-big-deal/