Abstract Regulation of global transcription output is important for normal development and disease. but little is known about the mechanisms involved. DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription. Here. https://www.roneverhart.com/Open-Box-Apple-Watch-Series-6-GPS-Cellular-40mm-Space-Gray-Aluminum-w-Black-Sport-Band/